Investigation of the antimicrobial properties of temperature-sensitive hydrogel containing silver sulfadiazine against various bacterial strains

Maha Mohammad AL-Rajabi; Teow Yeit Haan; Safa Senan Mahmod; Khalil Abdelrazek Khalil

doi:10.58915/ijneam.v18i1.1700

Authors

Maha Mohammad AL-Rajabi Chemical Engineering Department, Faculty of Engineering Technology, Al-Balqa Applied University, Al Salt 19117, Jordan and Centre of Excellence for Biomass Utilization (CoEBU), Universiti Malaysia Perlis (UniMAP), 02600 Arau, Perlis, Malaysia
Teow Yeit Haan Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia; Research Centre for Sustainable Process Technology (CESPRO), Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia and Cleaner Production – UKM Research Group, Universiti Kebangsaan Malaysia, 43600 UKM, Malaysia
Safa Senan Mahmod Centre of Excellence for Biomass Utilization (CoEBU), Universiti Malaysia Perlis (UniMAP), 02600 Arau, Perlis, Malaysia and Engineering technology of chemical and petroleum industries. Northern technical University, 41002, Mosul, Iraq
Khalil Abdelrazek Khalil Department of Mechanical and Nuclear Engineering, College of Engineering, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates

DOI:

https://doi.org/10.58915/ijneam.v18i1.1700

Abstract

In burn wound management, infection poses a significant challenge, accounting for 75% of deaths in burn patients. Silver sulfadiazine is broadly used as an effective antibacterial agent for treating burns. Numerous researchers have explored various dosage forms of silver sulfadiazine, such as cream, ointment, topical spray, and hydrogel, for antimicrobial topical applications. Hydrogels offer appealing advantages over conventional drug delivery systems due to their sensitivity and responsiveness to stimuli, particularly temperature. Nevertheless, the comprehensive investigation of the antimicrobial properties of temperature-sensitive hydrogel containing silver sulfadiazine against different bacterial strains remains lacking. Thus, the main objective of the current study is to explore the antimicrobial properties of the temperature-sensitive hydrogel, incorporating silver sulfadiazine, against various bacterial strains colonized in burn wounds. To assess the antimicrobial activity of the temperature-sensitive hydrogel, inhibition zone diameters were measured against different types of Gram-positive strains (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus pyogenes) and Gram-negative strains (Escherichia coli and Klebsiella pneumoniae). The synthesized silver sulfadiazine-loaded temperature-sensitive hydrogel exhibited remarkable antimicrobial efficacy against these bacteria. Notably, there was no significant difference in the inhibition zone diameter between the silver sulfadiazine-loaded temperature-sensitive hydrogel and the positive control (p>0.05). These findings affirm that the silver sulfadiazine-loaded temperature-sensitive hydrogel holds promise as a drug delivery medium, demonstrating excellent antimicrobial activity against various bacterial strains that colonized in burn wounds.