Application of the extracted microcrystalline cellulose from pineapple leaf fibers for wound dressing materials

Abstract

The wound healing process involves replacing damaged tissue through a series of cellular events. Microtechnology has the potential to provide the specific physicochemical properties and biological responses necessary to facilitate and support the wound healing process. Many natural biopolymers have been developed in the design of wound dressings. Hydroxyapatite and collagen exhibit antibacterial effects, anti-inflammatory and hydrophilic properties that can support wound treatment and prevent infection. Meanwhile, cellulose has been developed a lot regarding the utilization of its mechanical properties. This research aims to analyze the effect of variations in microcrystalline cellulose (MCC) composition on the physical and mechanical properties of HA/collagen composite scaffolds. The samples obtained were characterized by XRD, SEM, EDS, and UTM. The cellulose sample showed a diffraction peak at 21.7°, which increased significantly in the MCC spectrum. The intensity value was higher after going through the hydrolysis process, indicating that the hydrolysis process was able to increase the MCC intensity with a crystallinity index reaching 70.2%. The addition of MCC in the HA/collagen composite scaffold had an impact on increasing the strain value by 63.77% and relatively reducing the fiber diameter and membrane porosity.